Scientists accidentally discovered an antibody that could directly convert bone marrow stem cells into neural precursor cells while screening antibodies. Scientists believe that the transformation of patients' own cells can effectively treat spinal cord injury, stroke and other diseases, and this therapy has the lowest risk of immune rejection. However, the cell transformation techniques commonly used by people are relatively complicated, and most of them are only effective in in vitro experiments. This new discovery provides researchers with a simpler and safer way. The researchers screened the antibody library for antibodies that activate specific receptors on bone marrow stem cells. They analyzed the selected antibodies and found that the antibodies not only activated the corresponding receptors, but also induced the transformation of bone marrow stem cells into neural precursor cells. Bone marrow stem cells usually differentiate into white blood cells. Natural antibodies are Y-type proteins produced by immune cells. In the 1980s, Lerner and his colleagues at TSRI established a large antibody library for the first time and quickly screened for antibodies that bind a given target. Last year, Lerner's laboratory developed a new technology. Research shows that antibodies may become universal operons for cell functions, allowing researchers to select antibodies that activate a given receptor and change cell functions. The GCSF receptor is a growth factor receptor on bone marrow stem cells. Xie found antibodies that can activate the GCSF receptor and stimulate cell growth through new screening techniques. Subsequently, the researchers used human bone marrow stem cells cultured in vitro to test this antibody. In this new study, Jia Xie, a research assistant in Lerner's laboratory, improved the above technology so that the antibody protein produced by the cell is anchored outside the cell membrane, adjacent to its target receptor. On this basis, they conducted faster screening of larger antibody libraries. "The cells began to proliferate, but at the same time they became elongated and attached to the bottom of the Petri dish," Xie said. After further verification, the researchers found that these cells actually transformed into neural precursor cells. It is exciting to activate bone marrow stem cells directly into nerve cells using only antibodies to activate a receptor. The researchers pointed out that this antibody can be injected directly into the patient's blood. After the antibody enters the bone marrow, the bone marrow stem cells can be transformed into neural precursor cells. " Said the professor. "This is very different from the traditional use of antibodies." Wireless electric dermapen,professional derma stamp pen,chargeable Dr.Pen,micro needling pen,automatic derma stamp Wireless electric dermapen,professional derma stamp pen,chargeable Dr.Pen,micro needling pen,automatic derma stamp Guangzhou Vantee Electronic Technology Co., Ltd. , https://www.finerroller.com
Stem cell transdifferentiation antibody ELISA kit