Every cell surface in our body is covered with dense sugar molecules, which play a key role in human development and disease. However, due to its complexity, it is still very difficult for scientists to understand the composition of these "glycans". Researchers from the Emory University School of Medicine recently conducted research on glycans through gene chip microarray technology and a method they call "shotgunglycomics". Emory's team has developed a new chemical method to attach a fluorescent dye to purified glycans, and then separate individual glycans into multiple small dots and fix them on slides for testing. A detailed description of this method was published this week in the journal Nature Methods. "These slides can separate and display all the glycans in the cells, so we can detect the substances that adhere to them. However, we still don't know the structure of these glycans at the moment." Senior author of the paper, Emory University Medical Dr. David Smith, director of the Center for Gastronomics and professor of biochemistry, said: "This is why we use the term 'shotgun' to describe our semi-random research approach." After confirming the practicability of this technology, the research team used it to detect a specific molecule that can be recognized by the self-reactive antibodies present in the blood of most patients with Lyme disease. Lyme disease is a disease caused by the infection of Treponema pallidum after a bite of a tick. In severe cases, the immune system of the patient will have an autoimmune response to the bacteria. "With this method we can analyze glycans, thus opening up a new way for the diagnosis of human autoimmune diseases, and it is possible to find new treatments that clear the body ’s autoreactive antibodies or inhibit their pathological attacks on cells. Method, "said Richard D. Cummings, the corresponding author and professor at Emory University School of Medicine. Compared with protein or DNA, it is more difficult to completely analyze the structure of glycans, because glycans can form a variety of branched structures, and each of the chain links may be chemically different. Cells contain thousands of different glycans, which usually adhere to proteins or lipids. Scientists use this "shotgun" method to first find a glycan spot that specifically binds to proteins such as antibodies or toxins, and then focus on this glucan spot and determine its complete sequence. This method can help researchers select more important glycans from thousands of glycans on glass slides. "The sugars present on glycoproteins or glycolipids play a decisive role in the function of these molecules," said PamelaMarino, a supervisor of the National Institute of General Medical Sciences' Glycobiology Research Fund, a member of the National Institutes of Health. The information in these sugar molecules and the mechanism by which they promote protein-protein interactions are crucial. This research was funded by the NIGMSEUREKA program's high-risk research, which confirmed that the new 'shotgun' method is suitable for parsing glycan codes and can be used for Examine the role of glycans in infection and immunity. " At present, the Emory research team has applied this method of "Sandball Glycomics" to red blood cells, tumor cells and brain-derived lipids. Cummings said: "This new technology can be used to find special sugar molecules displayed on cancer cells and has the potential to be used in the diagnosis or treatment of tumors." Hotel furniture refers to various types of furniture used in hotels, including hotel room furniture, public area furniture, restaurant furniture, etc. According to different functions and usage locations, hotel furniture can be divided into the following categories: Business Chair,Leisure Chairs,Dining Chairs,Banquet Chair Foshan Shengshi Zhihui Technology Co., Ltd. , https://www.officeroutdoorfurniture.com
1. Hotel room furniture: Hotel room furniture refers to various furniture used in hotel rooms, including beds, bedside tables, wardrobes, desks, dressing tables, chairs, etc. The design of guest room furniture should focus on comfort and practicality, while also considering aesthetics and environmental friendliness. The material of guest room furniture is usually high-quality wood or board, and finely processed and decorated to enhance the comfort and luxury of the guest room.
2. Public area furniture: Public area furniture refers to various furniture used in hotel public areas, including lobby furniture, conference room furniture, rest area furniture, etc. The design of furniture in public areas should focus on practicality and aesthetics, while also considering pedestrian flow and functional requirements. Durable materials such as metal, glass, and leather are usually chosen for furniture in public areas to improve its lifespan and wear resistance.
3. Restaurant furniture: Restaurant furniture refers to various furniture used in hotel restaurants, including dining tables, chairs, bars, wine cabinets, etc. The design of restaurant furniture should focus on comfort and aesthetics, while also considering the style and atmosphere of the restaurant. Restaurant furniture is usually made of durable materials such as solid wood, stainless steel, and plastic for easy cleaning and maintenance.
Overall, the classification of hotel furniture is based on its function and place of use. Different types of hotel furniture vary in design, material selection, and manufacturing techniques, but they all emphasize comfort, practicality, and aesthetics. The selection of hotel furniture should be based on the hotel's style and needs to enhance customer satisfaction and the hotel's image.
Scientists use new technology to analyze cell surface glycans