Science's latest decryption: where is the difference between the human brain and the monkey brain?

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An analysis published in Science on November 23 showed that the human brain is not only a larger version of the ancestral primate brain, but also full and distinct, compared to the molecules and cells in the brain tissue of chimpanzees and macaques. The difference.

Science's latest decryption: where is the difference between the human brain and the monkey brain?

The most significant differences between humans and other primates are found in the brain. The brain is the main organ that gives us a specific attribute to this species.

However, a new study led by Yale University has transcribed a transcriptome for 16 regions of the adult, chimpanzee and macaque brains. Single-cell transcriptome data reveal differences in gene expression of species in global, local, and specific cell types of primate brains. The study found that all regions of the human brain have molecular features that are very similar to our primate relatives, but some regions contain significant patterns of human gene activity. This marks the evolution of the brain and may contribute to our cognitive ability.

The first author, Andre MM Sousa, said, "Our brain is three times larger and has more cells, so the ability to handle things is stronger than chimpanzees or monkeys. However, different species also play a role in the function of individual cells and the formation of intercellular connections. There are obvious differences."

Despite the different brain sizes, the researchers found that primates have striking similarities in gene expression in 16 regions of the brain, even in the prefrontal cortex, a high-level learning place that distinguishes humans from other apes. However, this study suggests that the brain region that is most characteristic of human-specific gene expression is the striatum, a region of motion.

Even in the cerebellum, one of the oldest areas of evolution in the brain, and most likely to share similarities among species, there are also significant differences. The researchers discovered that a gene, ZP2, is active only in the human cerebellum. The researchers said it was surprising because the gene has been identified to be related to the selection of sperm in human eggs.

The researchers also focused on a gene, TH, which is involved in the production of dopamine. Dopamine is a neurotransmitter that is essential for higher-order functions. People with Parkinson's disease have problems with this gene. They found that TH is abundantly expressed in human neocortex and striatum, but not in the cerebral cortex of chimpanzees.

Sousa said: "The expression of this gene in the neocortex may be lost in a common ancestor and reappear in the human lineage."

The researchers also found that genes associated with autism spectrum disorders were more expressed in the human prefrontal cortex than other primates.

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