Japanese ATAGO refractometer successfully applied in the pharmaceutical industry

Refractive index (also known as refractive index, refractive index RI) is the physical constant of a substance. Pure substances in solid, liquid and gas all have a certain refractive index. If it contains impurities, the refractive index will change. The more impurities, the greater the deviation. Therefore, the refractive index is often used as the basis for detecting the concentration, purity, and identification of unknown samples of raw materials, solvents, intermediates, and final products.

ATAGO fully automatic polarimeter (model: AP-300) is used to test the specific rotation of raw materials, intermediates, and finished products; the sugar industry mainly uses polarimeter to detect the purity of sugar.

Product features overview:

• International Brix (Temperature Compensation) scale to detect optical rotation during measurement

• Perform temperature correction with the temperature,

• Without constant temperature sample tube, it automatically displays accurate international sugar content

• Can store 10 kinds of optical tube information, automatic calculation.

• Rich selection of accessories

Refractive index is a very important parameter for APIs. Refractive index can be used to quickly and easily detect the purity and content of certain drugs. In addition, the refractive index is also often used to detect the concentration and concentration of traditional Chinese medicine decoction Control the quality of Chinese herbal medicine decoction. "Pharmacopoeia" is a quality standard that all pharmaceutical companies in the world must follow in the process of research, development, production and determination of pharmaceutical substances. Pharmaceutical substances include not only medicines and intravenous drugs, but also cosmetics and health products. The Pharmacopoeia contains many reference values, such as the refractive index and optical rotation / specific optical rotation of raw materials, so refractometers and polarimeters have an important role in the pharmaceutical industry.

"Chinese Pharmacopoeia" stipulates the refractive index measurement method, using the sodium spectrum D line (589.3 nm) to measure the refractive index of the test article relative to air (such as an Abbe refractometer, a white light source can be used). Unless otherwise specified, the temperature of the test sample is 20 ° C. Repeat the reading twice after the measurement, and the average of the three readings is the refractive index of the test product. The refractometer used for measurement needs to be able to read to 0.0001.

Japan ATAGO (love extension) specializes in manufacturing refractometer for more than 70 years, is a leader in refractometer and polarimeter. Its refractometer products include NAR-1T Abbe refractometer, NAR-3T precision Abbe refractometer, DR-A1 digital Abbe refractometer and RX-5000α, RX-5000α-plus, RX-7000α, RX-9000α Wait for fully automatic desktop digital display refractometer, etc. In addition, PAL-RI, PAL-BX / RI handheld digital refractometer and MARSTER-RI handheld scale refractometer were also developed. These instruments can be conveniently used in laboratories and testing institutions for precision testing and rapid testing.

Although the Abbe refractometer can meet the minimum requirements of the Pharmacopoeia, it requires an external water bath device. The measurement results often vary according to the operator, and the experimental results cannot be transmitted or automatically recorded. There are also many users in the industry. Some special models of Abbe refractometers, such as ATAGO's NAR-1T LO, have some special applications that can be used to measure samples with low RI values, such as liquid anesthetics (about 1.27 RI). The fully automatic desktop digital refractometer has the advantages of high precision, accurate temperature control, convenient and fast measurement, etc., so it is used by more and more pharmaceutical companies. ATAGO RX series automatic desktop digital display refractometer with Peltier temperature control device, no need for water bath, can achieve precise temperature control; and has extremely high accuracy, measurement accuracy can reach five decimal places (± 0.00002 RI).

Attachment: Refractive index of APIs commonly used in Pharmacopoeia

Vitamin E 1.494 ~ 1.499

Benzyl alcohol 1.538 ~ 1.541

Propionic anhydride 1.403 ~ 1.405

Phenylpropanol 1.517 ~ 1.522

Peppermint oil 1.456 ~ 1.466

Soybean oil 1.472 ~ 1.476

Japanese ATAGO refractometer successfully applied in the pharmaceutical industry

Japan ATAGO (Ai Tuo) automatic polarimeter application in the sugar, pharmaceutical industry

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