Major discovery! Enzyme DNASE1L3 can be used to treat autoimmune diseases such as lupus On June 11, 2016, in a new study, researchers from institutions such as the University of New York's Langone Medical Center found that when cells die, an enzyme cannot degrade and release into the bloodstream. DNA in may be a major trigger for inflammation in lupus. The results of the study were published online in the June issue of the journal Cell, entitled "Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity". The study targets the sustained and healthy turnover of mammalian cells, in which mammalian cells die and degrade, allowing their components, including DNA, to be recycled. In this new study, the researchers found that the enzyme DNASE1L3 normally digests the DNA in the microparticles released from cell breakage, thus preventing lupus. If DNASE1L3 does not prevent DNA accumulation, then DNA accumulation triggers immune cells to produce antibodies that capture and remove the DNA. Such antibodies, when combined with DNA to form complexes, enter the arterial wall and tissues, which can lead to inflammation, which causes damage to blood vessels, skin, joints and kidneys, which are the most severe forms of lupus--- Systemic lupus erythematosus (SLE) - part of the symptoms. Dr. Boris Reizis, Ph.D., author of the paper and professor of pathology and medicine at the Lange Medical Center at New York University, said, "Our research reveals a new mechanism that could be used to develop treatments for lupus and other autoimmune diseases. therapy." In particular, researchers have been able to reconstitute lupus disease processes through genetic modification of mice lacking the DNASE1L3-encoding gene, including anti-DNA antibody formation and kidney inflammation. Reizis said, "We also confirmed that patients who lack the DNASE1L3 gene or the DNASE1L3 gene do not function have a large amount of circulating DNA and produce antibodies against it, and such antibodies are also present in most lupus patients. This will be developed A new treatment offers a potential route, including the possibility of taking DNASE1L3 as a drug." Reizis added that the need for new therapies is urgent, because in the past 50 years, little progress has been made in developing methods for treating lupus, and the drugs traditionally taken are less tolerant. Fan Toy,Small Toy Fan,Mini Toy Fan,Bubble Fan Toy Shantou Chenghai LeTime Trading Co., Ltd , https://www.letimetoys.com
Enzyme DNASE1L3 may treat autoimmune diseases such as lupus